| Author(s) | I. AI-Jammaz, *M.K. AI-Sadoon** and A. Fahim*** |
| Affiliation | *Department of Biology, College of Teachers, P.O. Box 4341, Riyadh, 11491, Saudi Arabia, **Department of Zoology, College of Science, King Saud University, P.O.Box 2455, Riyadh, Saudi Arabia "'*Department of Science, Faculty of Teachers, P.O.Box2313, Al-Hasa 3912, Saudi Arabia. |
| Title | Effect of LDsoDose of Echis coloratus Venom on Serum and Tissue |
| Source | Journal of King Saud University. Science. Volume 11, No 2. (1999/1419) |
| Abstract | A single IDso dose of Echis coloratus venom - A Saudi viper - was found to cause sever hyperglycemia with decrease serum total lipids and unchanged serum total protein. These changes were simultaneous, with significant elevation in AST, IDH and intact ALT serum enzymes level. The envenomation also caused significant accumulation of glycogen in liver and kidney, but muscle glycogen was unaffected. Total lipid content of liver was found to be significantly higher than control, while a dramatic decrease was observed in both kidney and muscle. In addition, total protein was significantly decreased in liver, kidney and muscle. Regarding tissue enzymes activities, AST level was significantly decreased in all organs studied, while ALT level was significantly decreased in liver and muscle and significantly increased in kidney. IDH enzyme activity was noted to augment significantly in liver and muscle, with significant decline in its level in kidney. It is concluded that the snake venom may cause disturbance in the metabolic and enzymatic pathways of different vital organs manifested by the hyperglycemia and elevated AST and IDH serum enzymes levels. |
