| Author(s) | Maisaa M. AL-Rawi |
| Affiliation | Science Department, College of Education for Girls, Makkah, Saudi Arabia |
| Title | Biochemical and Histological Studies on the Effect of Hormonal Replacement Therapy in the Old Female Rats (Rattus norvegicus) |
| Source | Journal of King Saud University. Science. Volume 15, No 1. (2003/1423) |
| Abstract | Abstract. Estrogen (E) and/or progesterone (P) are mainly metabolized in liver and execrated in kidney. The present work was carried out to find out its effect on liver and kidney in old female albino rats. The intramuscular injection of Folone (estradiol benzoate, 90 μg/kg. b.wt,E) and/or Lutone (progesterone, 325 μg/kg.b.wt.,P) every 5 days for three months induced several biochemical and histological changes in both liver and kidney of treated animals. The biochemical parameters chosen for this study are serum liver function (ALp, GOT and GPT) which are sensitive parameters for the hepatic cells injury. Moreover, histological examination of the liver of estrogen- and/or progesterone- treated animals revealed destruction of the liver architecture, cytoplasmic vaculation of the hepatocytes, fatty infiltrates and a remarkable abundance of phagocytic infiltrates. On the other hand; the kidney showed marked changes of congestion, perivascular and interstitial lymphocytic infiltrations, degeneration of some renal corpuscles and renal tubules. Such cells showed progressive degeneration of their nuclei and necrosis. |
