| Author(s) | T. A. Kumosani |
| Affiliation | Biochemistry Department, Faculty of Science, P. O. Box 800 King Abdulaziz University, Jeddah 21589, Saudi Arabia |
| Title | Effect of Areca Nut Extracts on Some Organ Markers from Rat Serum in vivo |
| Source | Journal of King Saud University. Science. Volume 15, No 1. (2003/1423) |
| Abstract | Abstract: Areca nut (Areca catechu) is one of the plant species that possess beneficial pharmacological properties. It had an important place as a pharmaceutical in Ayurveda (the ancient Indian system for medicine) as well as in the Chinese medical practices. The pharmaceutical importance of areca nut is due to the presence of an alkaloid. This study was performed to provide some scientific grounds to understand some of the biochemical and pharmacological properties of areca nut. Extraction of the active ingredients of areca nut was performed by using two solvents of different polarities (n- hexane and methanol). The extracts were tested on some organ markers from rat serum in vivo, including some key enzymes such as Alkaline Phosphatase (ALP), Lactate Dehydrogenase (LDH), Glutamate Pyruvate Transaminase (GPT), Glutamate Oxaloacetate Transaminase (GOT), Gamma-Glutamyl Transferase (GGT), Creatine Phosphokinase (CPK); and other parameters which include glucose, cholesterol, total protein and urea. Those biochemical parameters were measured for both control and treated rats. The results showed significant changes in their activities compared to the control. Keywords: Areca nut, hexane, methanol, Wister white rat, ALP, LDH, GPT, GOT, GGT, CPK, glucose, cholesterol, total protein and urea. |
