| Author(s) | Ibrahim. A. Al-Jammaz |
| Affiliation | Science Department, College of Teachers, P.O. Box 4341, Riyadh 11491, Saudi Arabia |
| Title | Physiological Effects of LD50 of Echis coloratus Crude Venom on Rat at Different Time Intervals |
| Source | Journal of King Saud University. Science. Volume 15, No 2. (2003/1423) |
| Abstract | Abstract. Variations in physiological parameters of rat serum following snake venom administration can be used in assessing the functions of vital organs of envenomated subjects. In the present study the effects of LD50 of Echis coloratus crude venom on the serum physiological parameters of white rats were investigated over various periods of time. The snake venom has induced a reduction of serum total proteins, albumin, uric acid, phosphorus, calcium and sodium levels, as well as, the activity of LDH. Serum urea, total bilirubin, creatinine, glucose, triglycerides, and iron levels, as well as the activities of ALT, ALP, AMY and AST have shown significant increment significantly in some of the envenomated rats. Hence, E. coloratus crude venom seems to disturb the function of some vital organs of rat, such as liver, heart, kidney and skeletal muscles. Such disturbances appear to have variable durations. |
