| Author(s) | Mohammad A.M. Wadaan |
| Affiliation | Department of Zoology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia |
| Title | Toxicological Evaluation of Synthetic Detergent-induced |
| Source | Journal of King Saud University. Science. Volume 19, No 1. (2007/1427) |
| Abstract | Abstract. Toxicological evaluation of synthetic detergent was carried out by exposing the rat skin to the test solution of the commercial detergent in three concentrations (1%, 2.5% and 5%). The skin was exposed daily for one hour for five consecutive days. The skin reaction to the detergent was scored daily, whereas the enzymatic activities in the treated and control skin segments were determined on the fifth day after scoring the skin reaction. The exposed skin showed oedematous changes with erythema and cracking and/or scaling of the skin. The enzymes acid phosphatase (AcPase), glucose-6-phosphate dehydrogenase (G6PDH), glutamate oxaloacetate transaminase (GOT) and glutamate pyruvate transaminase (GPT) were stimulated significantly in the skin of the treated rats. A dose dependent effect was observed in skin reactions and enzymatic activities. Precautionary measures for skin protection from detergents are suggested. |
