| Author(s) | öAouacheri W., Saka Saad and Djafer R. |
| Affiliation | Department of Biochemistry, Faculty of Sciences, University of Badji, Mokhtar, Annaba, PO Box 12, Annaba 23000, Algeria |
| Title | Effect of Alphamethrin on Glutathione Redox System in Rats |
| Source | Journal of King Saud University. Agricultural Sciences. Volume 18, No 1. (2006/1426) |
| Abstract | Data are presented on the hepatic glutathione content and on the activity of two main enzymes involved in oxidoreduction reactions of glutathione (glutathione peroxidase and glutathione reductase) in the rat’s liver treated with 85 mg/kg (1/10th of an LD 50 dose) of an insecticide alphamethrin for 2 hours. The results indicate that the treatment with 1/10th of an LD 50 of alphamethrin can affect the glutathione redox system. However, the exposure to alphamethrin resulted in a 60% reduction (P<0.001) in reduced hepatic glutathione. The glutathione peroxidase activity, which is involved in the detoxification of peroxide compounds arising from alphamethrin metabolites, increases by 52% (P<0.05). Similarly, the glutathione reductase increases by 52% (P<0.001). Despite the increased activity of glutathione reductase, it is not in correlate with the decrease in glutathione content (60%) to maintain a stable ratio of GSH/GSSG. Keywords: Glutathione, Glutathione peroxidase, Glutathione reductase, Alphamethrin, Rats. |
