| Author(s) | S. A. Al-Essa, J. Y. Al-Homady and H. A. Ghulikah |
| Affiliation | Girls' College of Education, Department of Chemistry P.O. Box 53506, Riyadh 11593, Saudi Arabia |
| Title | Synthesis and Antimicrobial Study of Several New 3-Aryl –5(9'- Phenanthryl)-Azoles |
| Source | Journal of King Saud University. Science. Volume 16, No 2. (2004/1424) |
| Abstract | Phenanthryl chalcones (1) reacts with hydrazine hydrate and phenyl hydrazine to produce 2-pyrazloline derivatives (3) and (4) respectively. Acetylation of (3) gave (5) which can obtained also from compounds (1). Oxidation of compound (1) afforded oxirane derivatives (6). Isoxazolines (7) were also prepared. Compounds (7) reacted with N-bromosuccinimide and yielded isoxazoles (8). These isoxazoles have been prepared from chalcones (1) and oxirane derivatives (6). Reaction of (7) with phosphours pentasulphide leads to the formation of 2-isothiazoline derivatives (9). The biological activity of the prepared compounds were also studied. |
