| Author(s) | Ahmed R. Alhimaidi |
| Affiliation | Zoology Department, College of Science, King Saud University. P.O.Box. 2544, Riydh, Saudi Arabia 11451 E-mail: ahimaidi@ksu.edu.sa |
| Title | Tamoxifen Prevents Implantation of the Mice Embryos with no Side Effect Post Implantation |
| Source | Journal of King Saud University. Science. Volume 16, No 1. (2004/1424) |
| Abstract | This study was conducted to determine the effect of tamoxifen on the implantation rate and if it has any effect on the morphological changes of the embryo post implantation. Tamoxifen , in a single dose, (10mg/kg) was ingested orally to two groups of pregnant female's mice. In the first group, the ingestion was performed before implantation (day3-5 post coitus), and in the second after implantation (day 7-12 post coitus). Non of the females of the first group get pregnant, while in the second group all of them continue their pregnancy without any effect on the mean number, body or placenta weight of the embryos. There were no observed morphological abnormalities on the embryos compared with the control groups. Also there were no significant differences in the mean body weight gain of the females from the day of treatment up to day 17 of pregnancy of both treated and control groups. Based on the results of the present study, it can be concluded that tamoxifen prevents implantation of the embryos due to its binding to the estrogen receptors in the wall of the uterus with no side effect on the post implanted embryos. Keywords: Tamoxifen, embryo, implantation. |
